Article

Decoding WNT Pathway Dysregulation in Bevacizumab-Treated Early-Onset Colorectal Cancer to Inform Precision Oncology

2025-12-23

Abstract excerpt

Early-onset colorectal cancer (EOCRC) is rising most rapidly among Hispanic/Latino (H/L) populations, yet the prognostic relevance of WNT pathway alterations under contemporary therapies remains unclear. We conducted a multi-cohort analysis integrating somatic genomics with clinical and treatment annotations (including bevacizumab exposure) from public CRC datasets, stratifying by age of onset and ancestry (H/L vs...

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Literature Corpus work: ff5eb759-4bf2-5659-95b7-1cee24dbf778
DOI: 10.64898/2025.12.22.25342868

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