Article
RNA Sensing and Innate Immunity Constitutes a Barrier for Interspecies Chimerism
2023-03-09
Abstract excerpt
Interspecies chimera formation with human pluripotent stem cells (PSCs) holds great promise to generate humanized animal models and provide donor organs for transplant. However, the approach is currently limited by low levels of human cells ultimately represented in chimeric embryos. Different strategies have been developed to improve chimerism by genetically editing donor human PSCs. To date, however, it remains...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 60820262-c16b-570c-b95a-2d20cc32f1d2
- DOI
- 10.1101/2023.03.07.531624