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Article

Human-Mouse Chimerism Validates Human Stem Cell Pluripotency

18 Dec 2015

Abstract excerpt

Pluripotent stem cells are defined by their capacity to differentiate into all three tissue layers that comprise the body. Chimera formation, generated by stem cell transplantation to the embryo, is a stringent assessment of stem cell pluripotency. However, the ability of human pluripotent stem cells (hPSCs) to form embryonic chimeras remains in question. Here we show using a stage-matching approach that human...

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Identifiers

PMID: 26712580
DOI: 10.1016/j.stem.2015.11.017

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