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BMI1 enables interspecies chimerism with human pluripotent stem cells

1 Nov 2018

Abstract excerpt

Human pluripotent stem cells (hPSCs) exhibit very limited contribution to interspecies chimeras. One explanation is that the conventional hPSCs are in a primed state and so unable to form chimeras in pre-implantation embryos. Here, we show that the conventional hPSCs undergo rapid apoptosis when injected into mouse pre-implantation embryos. While, forced-expression of BMI1, a polycomb factor in hPSCs overcomes...

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PMID: 30405129
DOI: 10.1038/s41467-018-07098-w

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