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Article

Xenophagocytosis blockade enhances interspecies chimerism

2025-10-15

Abstract excerpt

<h4>SUMMARY</h4> Organ shortage remains a major challenge in transplantation medicine. Interspecies blastocyst complementation is a promising approach to generate human organs in livestock hosts. However, getting xenogeneic donor cells to engraft and expand at early stages remains challenging. Here we identify an innate immune barrier, wherein host macrophages selectively recognize and eliminate viable xenogeneic...

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Literature Corpus work
c1e5288c-fbbb-5946-ad7c-b518c4fcf8a7
DOI
10.1101/2025.10.14.682291
Open publication

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Xenophagocytosis blockade enhances interspecies chimerismDOI 10.1101/2025.10.14.682291
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