Article

Generating Functional Cells Through Enhanced Interspecies Chimerism with Human Pluripotent Stem Cells

2022-02-10

Abstract excerpt

Obtaining functional human cells through interspecies chimerism with human pluripotent stem cells (hPSCs) remains unsuccessful due to its extreamly low efficiency. Here, we show that hPSCs failed to differentiate and contribute teratoma in presence of mouse PSCs (mPSCs). While, MYCN, a pro-growth factor dramatically promotes hPSC contribution in teratoma co-formation by hPSCs/mPSCs. MYCN combined with BCL2 (M/B) g...

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Literature Corpus work: 2e38c744-2dd6-5675-a0f4-6fb93f1bb25c
DOI: 10.1101/2022.02.10.479858

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