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Spatial Transcriptomics Reveals <i>CXCL12</i> ⁺ Fibroblasts as Central Immune Organizers through CXCR4 Signaling in Abdominal Aortic Aneurysm

2025-11-29

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Abdominal aortic aneurysm (AAA) is characterized by sterile inflammation, immune cell infiltration, and stromal remodeling that progressively weaken the aortic wall, leading to life-threatening aortic rupture. The molecular mechanisms and spatial organization of immune–stromal interactions in human tissue are poorly understood, limiting the potential to develop effective pha...

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Literature Corpus work
0ed7ba31-ffd4-553b-8f5c-10a02b818774
DOI
10.1101/2025.11.24.690328
Open publication

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Spatial Transcriptomics Reveals <i>CXCL12</i> ⁺ Fibroblasts as Central Immune Organizers through CXCR4 Signaling in Abdominal Aortic AneurysmDOI 10.1101/2025.11.24.690328
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