Article

Single-cell transcriptomics-based multidisease analysis revealing the molecular dynamics of retinal neurovascular units under inflammatory and hypoxic conditions

2022-07-29

Abstract excerpt

The retinal neurovascular unit (NVU) is paramount to maintaining the homeostasis of the retina and determines the progression of various diseases, including diabetic retinopathy (DR), glaucoma, and retinopathy of prematurity (ROP). Although some studies have investigated these diseases, a combined analysis of disease-wide etiology in the NUV at the single-cell level is lacking. Herein, we constructed an atlas of t...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1c30fb9e-96f9-562a-9094-47f3fd8b6dea
DOI: 10.21203/rs.3.rs-1888726/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptomics-based multidisease analysis revealing the molecular dynamics of retinal neurovascular units under inflammatory and hypoxic conditionsDOI 10.21203/rs.3.rs-1888726/v1Read

Single-cell transcriptomics-based multidisease analysis revealing the molecular dynamics of retinal neurovascular units under inflammatory and hypoxic conditionsSemantic proximity Read

Single-cell RNA sequencing reveals the Müller subtypes and inner blood–retinal barrier regulatory network in early diabetic retinopathySemantic proximity Read

AI-Driven Analysis Unveils Functional Dynamics of Müller Cells in Retinal Autoimmune InflammationSemantic proximity Read

Single-cell profiling reveals an endothelium-mediated immunomodulatory pathway in the eye choroidSemantic proximity Read

Single-cell transcriptomic analysis revealing changes in retinal cell subpopulation levels and the pathways involved in diabetic retinopathySemantic proximity Read

Implication of specific retinal cell-type involvement and gene expression changes in AMD progression using integrative analysis of single-cell and bulk RNA-seq profilingSemantic proximity Read

Single-Cell Transcriptomics Reveals Novel Role of Microglia in Fibrovascular Membrane of Proliferative Diabetic RetinopathySemantic proximity Read

Pathogenesis Study Based on High-Throughput Single-Cell Sequencing Analysis Reveals Novel Transcriptional Landscape and Heterogeneity of Retinal Cells in Type 2 Diabetic MiceSemantic proximity Read

Bulk Gene Expression Deconvolution Reveals Infiltration of M2 Macrophages in Retinal NeovascularizationSemantic proximity Read

Transcriptomic Analysis of the Ocular Posterior Segment Completes a Cell Atlas of the Human EyeSemantic proximity Read

Single-cell analysis of the human retina reveals stage-linked microglial states and neural-immune circuit rewiring in diabetic retinopathySemantic proximity Read

Single-cell transcriptome analysis of the Akimba mouse retina reveals cell-type-specific insights into the pathobiology of diabetic retinopathySemantic proximity Read