Article
Single-cell gene expression patterns in lupus monocytes independently indicate disease activity, interferon and therapy
25 Jun 2017
Abstract excerpt
OBJECTIVES: Important findings can be masked in gene expression studies of mixed cell populations. We examined single-cell gene expression in SLE patient monocytes in the context of clinical and immunological features. METHODS: Monocytes were purified from patients with SLE and controls, and individually isolated for single-cell gene expression measurement. A panel of monocyte-related transcripts were measured in...
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