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Epigenetic Regulation of Erythropoiesis: From Developmental Programs to Therapeutic Targets

30 Jun 2025

Abstract excerpt

Erythropoiesis, the process driving the differentiation of hematopoietic stem and progenitor cells to mature erythrocytes, unfolds through tightly orchestrated developmental stages, each defined by profound epigenetic remodeling. From the initial commitment of hematopoietic progenitors to the terminal enucleation of erythrocytes, dynamic changes in chromatin accessibility, transcription factor occupancy, and...

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PMID: 40650116
DOI: 10.3390/ijms26136342

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