Article

Opposing selective forces operating on human-specific duplicated TCAF genes in Neanderthals and humans

2020-10-01

Abstract excerpt

<title>Abstract</title> <p>TRP channel-associated factor 1/2 (TCAF1/TCAF2) proteins antagonistically regulate the cold-sensor protein TRPM8 in multiple human tissues. Understanding their significance has been complicated given the locus spans a gap-ridden region with complex segmental duplications in GRCh38. Using long-read sequencing, we sequence-resolve the locus, annotate full-length <italic>TCAF</italic> mode...

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Literature Corpus work: 60627f9d-7165-5d1c-b705-ebc5321c885f
DOI: 10.21203/rs.3.rs-77798/v1

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