Article

Human-specific gene expansions contribute to brain evolution

2024-09-26

Abstract excerpt

<h4>Summary</h4> Duplicated genes expanded in the human lineage likely contributed to brain evolution, yet challenges exist in their discovery due to sequence-assembly errors. We used a complete telomere-to-telomere genome sequence to identify 213 human-specific gene families. From these, 362 paralogs were found in all modern human genomes tested and brain transcriptomes, making them top candidates contributing t...

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Literature Corpus work: 08f59320-533b-5868-ac30-601fa150ad4a
DOI: 10.1101/2024.09.26.615256

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