Article
Parkin protects against LRRK2 G2019S mutant-induced dopaminergic neurodegeneration in Drosophila.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 9 Sept 2009
Ng Chee-Hoe, Mok Shaun Z S, Koh Cherlyn, Ouyang Xuezhi, Fivaz Marc L, Tan Eng-King, Dawson Valina L, Dawson Ted M, Yu Fengwei, Lim Kah-Leong
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are currently recognized as the most common genetic cause of parkinsonism. Among the large number of LRRK2 mutations identified to date, the G2019S variant is the most common. In Asia, however, another LRRK2 variant, G2385R, appears to occur more frequently. To better understand the contribution of different LRRK2 variants toward disease pathogenesis, we...
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