Article

Altered MAM function shifts mitochondrial metabolism in SOD1-mutant models of ALS

2022-09-22

Abstract excerpt

Mitochondrial defects are a common hallmark of familial and sporadic forms of amyotrophic lateral sclerosis (ALS). However, the origin of these defects, including reduced pyruvate metabolism and reduced oxygen consumption, is poorly understood. These metabolic functions are regulated in specialized endoplasmic reticulum (ER) domains in close contact with mitochondria, called mitochondrial-associated ER membranes (...

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Literature Corpus work: 75497cd4-06b6-53e5-81dd-fee3f40599e5
DOI: 10.1101/2022.09.22.508778

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