Article
Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.
Nature neuroscience - 1 Nov 2009
Grathwohl Stefan A, Kälin Roland E, Bolmont Tristan, Prokop Stefan, Winkelmann Georg, Kaeser Stephan A, Odenthal Jörg, Radde Rebecca, Eldh Therese, Gandy Sam, Aguzzi Adriano, Staufenbiel Matthias, Mathews Paul M, Wolburg Hartwig, Heppner Frank L, Jucker Mathias
Abstract excerpt
In Alzheimer's disease, microglia cluster around beta-amyloid deposits, suggesting that these cells are important for amyloid plaque formation, maintenance and/or clearance. We crossed two distinct APP transgenic mouse strains with CD11b-HSVTK mice, in which nearly complete ablation of microglia was achieved for up to 4 weeks after ganciclovir application. Neither amyloid plaque formation and maintenance nor...
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