Article

Spontaneous Mutations in HIV-1 Gag, protease, RT p66 in the first replication cycle and how they appear: Insights from an <i>in vitro</i> BSL2 assay on mutation rates and types

2019-06-23

Abstract excerpt

While drug resistant mutations in HIV-1 is largely credited to its error prone HIV-1 RT, host proteins such as deaminases may also play a role generating mutations. Many HIV-1 RT mutational in vitro studies utilize reporter genes (LacZ) as template, leaving out the possible contribution of HIV codon usage and gene-specific effects. To address this gap, we studied HIV-1 RT mutation rates and bias on its own Gag, p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6037c9b5-1772-59fa-a582-8a26fd63971b
DOI: 10.1101/679852

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spontaneous Mutations in HIV-1 Gag, protease, RT p66 in the first replication cycle and how they appear: Insights from an <i>in vitro</i> BSL2 assay on mutation rates and typesDOI 10.1101/679852Read

Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types.Semantic proximity Read

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Semantic proximity Read

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.Semantic proximity Read

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug ResistanceSemantic proximity Read

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance.Semantic proximity Read

Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.Semantic proximity Read

HIV-1 tolerates changes in A-count in a small segment of the pol gene.Semantic proximity Read

Lamivudine/Adefovir Treatment Increases the Rate of Spontaneous Mutation of Hepatitis B Virus in Patients.Semantic proximity Read

Sexual transmission of HIV-1 isolate showing G-->A hypermutation.Semantic proximity Read

Within-patient mutation frequencies reveal fitness costs of CpG dinucleotides and drastic amino acid changes in HIVSemantic proximity Read

Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.Semantic proximity Read

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.Semantic proximity Read