Article
Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations.
Nucleic acids research - 31 Mar 2015
Telwatte Sushama, Hearps Anna C, Johnson Adam, Latham Catherine F, Moore Katie, Agius Paul, Tachedjian Mary, Sonza Secondo, Sluis-Cremer Nicolas, Harrigan P Richard, Tachedjian Gilda
Abstract excerpt
Resistance to combined antiretroviral therapy (cART) in HIV-1-infected individuals is typically due to nonsynonymous mutations that change the protein sequence; however, the selection of synonymous or 'silent' mutations in the HIV-1 genome with cART has been reported. These silent K65K and K66K m...
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