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Article

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.

Journal of virology - 1 Jul 2014

Abram Michael E, Ferris Andrea L, Das Kalyan, Quinoñes Octavio, Shao Wei, Tuske Steven, Alvord W Gregory, Arnold Eddy, Hughes Stephen H

Abstract excerpt

UNLABELLED: The genetic variation in HIV-1 in patients is due to the high rate of viral replication, the high viral load, and the errors made during viral replication. Some of the mutations in reverse transcriptase (RT) that alter the deoxynucleoside triphosphate (dNTP)-binding pocket, including those that confer resistance to nucleoside/nucleotide analogs, affect dNTP selection during replication. The effects of...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 24760888
DOI: 10.1128/JVI.00302-14
PMCID: PMC4054409

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Source receipt: pubmed, retrieved 7 Sept 2026.

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