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Article

Increasing prevalence of K65K and K66K in HIV-1 subtype B reverse transcriptase.

AIDS (London, England) - 28 Nov 2016

Telwatte Sushama, Brumme Chanson J, Hearps Anna C, Latham Catherine F, Hayward Joshua A, Sonza Secondo, Sluis-Cremer Nicolas, Harrigan P Richard, Tachedjian Gilda

Abstract excerpt

OBJECTIVE: Synonymous substitutions K65K/K66K in HIV-1 reverse transcriptase alleviate fitness and fidelity defects in HIV-1 molecular clones harboring thymidine analogue mutations (TAMs); however, their potential for transmission and persistence is unknown. Here, we investigated the temporal appearance of K65K/K66K relative to TAMs in a HIV-1 cohort, their prevalence over time, and their impact on viral fitness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 27677159
DOI: 10.1097/QAD.0000000000001272

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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