Article

The Determination of HIV-1 RT Mutation Rate, Its Possible Allosteric Effects, and Its Implications on Drug Resistance

2020-02-07

Abstract excerpt

The high mutation rate of human immunodeficiency virus type 1 (HIV-1) plays a major role in treatment resistance from the development of vaccines to long-lasting drugs. In addressing the crux of the issue, various attempts to estimate the mutation rate of HIV-1 resulted in a large range of 10-5 - 10-3 errors/bp/cycle due to the use of different types of investigation methods. In this review, we discuss the differe...

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Literature Corpus work: 1e8e45e7-5261-5bdb-976c-b5ca31062a08
DOI: 10.20944/preprints202002.0099.v1

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