Article
Persistence of frequently transmitted drug-resistant HIV-1 variants can be explained by high viral replication capacity.
Retrovirology - 29 Nov 2014
Pingen Marieke, Wensing Annemarie M J, Fransen Katrien, De Bel Annelies, de Jong Dorien, Hoepelman Andy I M, Magiorkinis Emmanouil, Paraskevis Dimitrios, Lunar Maja M, Poljak Mario, Nijhuis Monique, Boucher Charles A B
Abstract excerpt
BACKGROUND: In approximately 10% of newly diagnosed individuals in Europe, HIV-1 variants harboring transmitted drug resistance mutations (TDRM) are detected. For some TDRM it has been shown that they revert to wild type while other mutations persist in the absence of therapy. To understand the mechanisms explaining persistence we investigated the in vivo evolution of frequently transmitted HIV-1 variants and...
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