Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.

Journal of virology - 1 Oct 2010

Abram Michael E, Ferris Andrea L, Shao Wei, Alvord W Gregory, Hughes Stephen H

Abstract excerpt

There is considerable HIV-1 variation in patients. The extent of the variation is due to the high rate of viral replication, the high viral load, and the errors made during viral replication. Mutations can arise from errors made either by host DNA-dependent RNA polymerase II or by HIV-1 reverse transcriptase (RT), but the relative contributions of these two enzymes to the mutation rate are unknown. In addition,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Frameshift Mutation
Share to Genes, Reporter
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to HIV Reverse Transcriptase

Share to INDEL Mutation

Share to Lac Operon

Share to Mutagenesis, Insertional

Source

Open in PubMed Open full text

Identifiers

PMID: 20660205
DOI: 10.1128/JVI.00915-10
PMCID: PMC2937799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.PMID 20660205Read ↗

Mutations in HIV-1 reverse transcriptase affect the errors made in a single cycle of viral replication.Semantic proximity Read ↗

Use of single-cycle analysis to study rates and mechanisms of retroviral mutation.Semantic proximity Read ↗

Lower in vivo mutation rate of human immunodeficiency virus type 1 than that predicted from the fidelity of purified reverse transcriptase.Semantic proximity Read ↗

Spontaneous Mutations in HIV-1 Gag, Protease, RT p66 in the First Replication Cycle and How They Appear: Insights from an In Vitro Assay on Mutation Rates and Types.Semantic proximity Read ↗

Mechanisms of retroviral mutation.Semantic proximity Read ↗

Analysis of mutations made during active synthesis or extension of mismatched substrates further define the mechanism of HIV-RT mutagenesis.Semantic proximity Read ↗

Rapid Determination of HIV-1 Mutant Frequencies and Mutation Spectra Using an mCherry/EGFP Dual-Reporter Viral Vector.Semantic proximity Read ↗

Fidelity of HIV-1 reverse transcriptase copying a hypervariable region of the HIV-1 env gene.Semantic proximity Read ↗

Differential Influence of Nucleoside Analog-resistance Mutations K65R and L74V on the Overall Mutation Rate and Error Specificity of Human Immunodeficiency Virus Type 1 Reverse TranscriptaseSemantic proximity Read ↗

Differential influence of nucleoside analog-resistance mutations K65R and L74V on the overall mutation rate and error specificity of human immunodeficiency virus type 1 reverse transcriptase.Semantic proximity Read ↗

Spontaneous Mutations in HIV-1 Gag, protease, RT p66 in the first replication cycle and how they appear: Insights from an <i>in vitro</i> BSL2 assay on mutation rates and typesSemantic proximity Read ↗

Mutational analysis of HIV-1 long terminal repeats to explore the relative contribution of reverse transcriptase and RNA polymerase II to viral mutagenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.