Article

Glomerular mTORC1 activation was associated with podocytes to endothelial cells communication in Lupus Nephritis

2022-07-29

Abstract excerpt

<title>Abstract</title> <p>Objective This study was initiated to evaluate the mammalian target of rapamycin (mTOR) signaling pathway involved in renal endothelial- podocyte crosstalk of lupus nephritis (LN) patients. Methods We compared the kidney protein expression patterns of 10 LN patients with severe endothelial- podocyte injury and 3 ones with moderate endothelial- podocyte injury on formalin-fixed paraffi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60352463-f4e7-5c68-ab26-2fae243938e0
DOI: 10.21203/rs.3.rs-1878924/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Glomerular mTORC1 activation was associated with podocytes to endothelial cells communication in Lupus NephritisDOI 10.21203/rs.3.rs-1878924/v1Read

Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritisSemantic proximity Read

Mammalian target of rapamycin signaling in the podocyteSemantic proximity Read

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.Semantic proximity Read

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritisSemantic proximity Read

Review: Mammalian Target of Rapamycin (mTOR) Pathway Is Critical in Developing Most Renal Cell Tumors.Semantic proximity Read

Role of mTOR signaling in the regulation of high glucose‑induced podocyte injurySemantic proximity Read

mTOR activation is a biomarker and a central pathway to autoimmune disorders, cancer, obesity, and agingSemantic proximity Read

The TXNIP–mTOR–Autophagy axis in diabetic kidney disease: mechanistic insights and therapeutic implicationsSemantic proximity Read

The targeted podocyte.Semantic proximity Read

miR-378a and NPNT coordinate autophagy regulation in podocytes through mTOR and MAPK signalingSemantic proximity Read

Microvesicles containing microRNA-21 secreted by proximal tubular epithelial cells are involved in renal interstitial fibrosis by activating AKT pathway.Semantic proximity Read

Loss of genome maintenance is linked to mTOR complex 1 signaling and accelerates podocyte damageSemantic proximity Read