Article
Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.
The Journal of clinical investigation - 1 Jun 2011
Gödel Markus, Hartleben Björn, Herbach Nadja, Liu Shuya, Zschiedrich Stefan, Lu Shun, Debreczeni-Mór Andrea, Lindenmeyer Maja T, Rastaldi Maria-Pia, Hartleben Götz, Wiech Thorsten, Fornoni Alessia, Nelson Robert G, Kretzler Matthias, Wanke Rüdiger, Pavenstädt Hermann, Kerjaschki Dontscho, Cohen Clemens D, Hall Michael N, Rüegg Markus A, Inoki Ken, Walz Gerd, Huber Tobias B
Abstract excerpt
Chronic glomerular diseases, associated with renal failure and cardiovascular morbidity, represent a major health issue. However, they remain poorly understood. Here we have reported that tightly controlled mTOR activity was crucial to maintaining glomerular podocyte function, while dysregulation...
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