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Article

Mammalian target of rapamycin signaling in the podocyte

1 Mar 2012

Abstract excerpt

PURPOSE OF REVIEW: Mammalian target of rapamycin (mTOR) is an evolutionarily conserved protein kinase. mTOR forms two distinct functional multiprotein kinase complexes that mutually phosphorylate different substrates and regulate a wide array of essential cellular processes including translation, transcription and autophagy. mTOR is active in several types of cancer and plays a role in a variety of other serious...

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PMID: 22388550
DOI: 10.1097/mnh.0b013e3283520f38

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