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Article

Renal mTORC1 activation is associated with disease activity and prognosis in lupus nephritis

13 Jan 2022

Abstract excerpt

OBJECTIVE: This study was initiated to evaluate mammalian target of rapamycin (mTOR) activation in renal tissue of LN patients. METHODS: This retrospective study included 187 LN patients, 20 diabetic nephropathy (DN) patients, 10 minimal change disease (MCD) patients and 10 normal controls (NCs). Seven of 187 LN patients had repeated renal biopsies. mTORC1/2 activation was evaluated by immunohistochemistry and...

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PMID: 35040950
DOI: 10.1093/rheumatology/keac037

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