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Article

Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis

3 Nov 2008

Abstract excerpt

INTRODUCTION: Treatment with sirolimus, a mammalian target of rapamycin (mTOR) inhibitor, has been shown to be efficacious in the MRL/lpr and NZB x NZW F1 mouse models of lupus nephritis, indicating a critical role for the mTOR pathway in both models. This type of demonstration of efficacy in animal models is usually a pre-requisite for advancement into clinical development. However, efficacy in an animal model...

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PMID: 18980674
DOI: 10.1186/ar2541

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