TASEP modelling provides a parsimonious explanation for the ability of a single uORF to upregulate downstream ORF translation during the Integrated Stress Response

Abstract excerpt

<h4>ABSTRACT</h4> Translation initiation is the rate limiting step of protein synthesis that is downregulated during Integrated Stress Response (ISR). In our previous work (Andreev, O’Connor et al 2015), we demonstrated that most human mRNAs resistant to this inhibition possess translated uORFs and in some cases a single uORF is sufficient for the resistance. Here we developed a computational model of Initiation...

Topics

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• Binding Sites
• Endoplasmic Reticulum Stress and Disease
• Eukaryotic Initiation Factor-3
• RNA and protein synthesis mechanisms
• RNA modifications and cancer
• RNA regulation and disease
• RNA Research and Splicing
• Viral Infections and Immunology Research

Identifiers and source

Literature Corpus work

3dc553b7-2386-5df0-9e78-974d5068a9c2

DOI

10.1101/204784