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Article

Impact of Genetic Predisposition to Obesity on Long-Term Maintenance of Modest Weight Loss in Postmenopausal Women.

Obesity (Silver Spring, Md.) - 1 Apr 2026

Lee Harold H, Avery Christy L, Graff Misa, Kim Daeeun, Arias Josh, Van Horn Linda, Kooperberg Charles, North Kari E

Abstract excerpt

OBJECTIVE: Long-term weight regain limits the population-level benefits of obesity interventions. We tested whether the polygenic risk score of BMI (PRSBMI) modifies weight trajectories following modest weight loss. METHODS: The analytic sample included 9897 postmenopausal women from the Women's Health Initiative Dietary Modification Trial (6132 European American; 3749 African American). PRSBMI was derived from a...

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Identifiers

PMID: 41792585
DOI: 10.1002/oby.70175
PMCID: PMC13032054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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