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The human telomeric nucleosome displays distinct structural and dynamic properties

5 May 2020

Abstract excerpt

Telomeres protect the ends of our chromosomes and are key to maintaining genomic integrity during cell division and differentiation. However, our knowledge of telomeric chromatin and nucleosome structure at the molecular level is limited. Here, we aimed to define the structure, dynamics as well as properties in solution of the human telomeric nucleosome. We first determined the 2.2 Å crystal structure of a human...

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PMID: 32374876
DOI: 10.1093/nar/gkaa289

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