Article

Accumulation of defense systems in phage resistant strains of <i>Pseudomonas aeruginosa</i>

2022-08-12

Abstract excerpt

Prokaryotes encode multiple distinct anti-phage defense systems in their genomes. However, the impact of carrying a multitude of defense systems on phage resistance remains unclear, especially in a clinical context. Using a collection of antibiotic-resistant clinical strains of Pseudomonas aeruginosa and a broad panel of phages, we demonstrate that defense systems contribute substantially to defining phage host r...

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Literature Corpus work: 1997540e-e1af-5e30-a3fd-0074025bd200
DOI: 10.1101/2022.08.12.503731

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