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H5N1 2.3.4.4b HA E190D and Q226H mutations, picked up as minority variants in a patient, result in an inability to bind sialic acid

2026-03-08

Abstract excerpt

A human infection with clade 2.3.4.4b H5N1 influenza A virus in Canada revealed minority variants E190D and Q226H in the hemagglutinin (HA) receptor-binding site (RBS). Because mutations at positions 190 and 226 have been associated with altered receptor specificity in other influenza subtypes, we investigated their impact on receptor binding in H5 HA. Using a recombinant protein approach and an ELISA-based glycan...

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Literature Corpus work: 5fec4ac8-fa0b-59af-9155-849c5414e18d
DOI: 10.64898/2026.03.06.710037

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