Article

Epistasis in the receptor binding domain of contemporary H3N2 viruses that reverted to bind sialylated diLacNAc repeats

2024-11-26

Abstract excerpt

Since the introduction of H3N2 influenza A viruses in the human population, these viruses have continuously evolved to escape human immunity, with mutations occurring in and around the receptor binding site. This process, called antigenic drift, recently resulted in viruses that recognize elongated glycans that are not abundantly displayed in the human respiratory tract. Such receptor specificities hampered our ab...

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Literature Corpus work: eafc0e3e-d2e5-536f-b2b5-86dc4f50dc08
DOI: 10.1101/2024.11.26.625384

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