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Article

In vitro evolution of H5N1 avian influenza virus toward human-type receptor specificity.

Virology - 5 Jan 2012

Chen Li-Mei, Blixt Ola, Stevens James, Lipatov Aleksandr S, Davis Charles T, Collins Brian E, Cox Nancy J, Paulson James C, Donis Ruben O

Abstract excerpt

Acquisition of α2-6 sialoside receptor specificity by α2-3 specific highly-pathogenic avian influenza viruses (H5N1) is thought to be a prerequisite for efficient transmission in humans. By in vitro selection for binding α2-6 sialosides, we identified four variant viruses with amino acid substitutions in the hemagglutinin (S227N, D187G, E190G, and Q196R) that revealed modestly increased α2-6 and minimally...

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Identifiers

PMID: 22056389
DOI: 10.1016/j.virol.2011.10.006
PMCID: PMC5480292

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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