Article

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antivirals

2026-07-28

Abstract excerpt

In late 2024, two individuals in Canada and the United States were treated in intensive care for acute respiratory distress caused by infection with the avian Influenza A Virus H5N1 2.3.4.4b genotype D1.1. Viral sequence data obtained from sampling these patients indicated mixed alleles at haemagglutinin (HA) positions 190 and 226. Mutations at these positions are key determinants of HA usage of α2,6-linked sialic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b794699f-8bc7-5e6a-a645-51e182df788b
DOI: 10.64898/2026.07.28.740943

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mutations in severe human H5N1 cases facilitate evasion from human mucus and antiviralsDOI 10.64898/2026.07.28.740943Read

Phenotypic effects of mutations observed in the neuraminidase of human origin H5N1 influenza A viruses.Semantic proximity Read

Mutation of the second sialic acid-binding site of influenza A virus neuraminidase drives compensatory mutations in hemagglutinin.Semantic proximity Read

Intra-patient neuraminidase mutations in avian H5N1 influenza virus reduce sialidase activity to complement weaker hemagglutinin binding and facilitate human infection.Semantic proximity Read

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.Semantic proximity Read

Avian Influenza Viruses Infect Primary Human Bronchial Epithelial Cells Unconstrained by Sialic Acid α2,3 ResiduesSemantic proximity Read

Hemagglutinin double-mutation enhances binding of human-infecting avian influenza virus clade 2.3.4.4b H5Ny to human and SLeX receptors.Semantic proximity Read

Genetic determinants of receptor-binding preference and zoonotic potential of H9N2 avian influenza virusesSemantic proximity Read

A Single Mutation at Position 190 in Hemagglutinin Enhances Binding Affinity for Human Type Sialic Acid Receptor and Replication of H9N2 Avian Influenza Virus in Mice.Semantic proximity Read

Phenotypic Effects of Substitutions within the Receptor Binding Site of Highly Pathogenic Avian Influenza H5N1 Virus Observed during Human InfectionSemantic proximity Read

Virulence-Associated Substitution D222G in the Hemagglutinin of 2009 Pandemic Influenza A(H1N1) Virus Affects Receptor BindingSemantic proximity Read

Epistasis in the receptor binding domain of contemporary H3N2 viruses that reverted to bind sialylated diLacNAc repeatsSemantic proximity Read

Sialic acid receptors: focus on their role in influenza infectionSemantic proximity Read