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The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors

15 Apr 2025

Abstract excerpt

H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of hosts in diverse climatic environments. Fortunately, transmission to and between humans is scarce. Yet, if such an event were to occur, it could spark a pandemic as humans are immunologically naïve to H5 viruses. A...

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PMID: 40232794
DOI: 10.1073/pnas.2419800122

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