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Article

The Q226L mutation can convert a highly pathogenic H5 2.3.4.4e virus to bind human-type receptors.

Proceedings of the National Academy of Sciences of the United States of America - 22 Apr 2025

Ríos Carrasco María, Lin Ting-Hui, Zhu Xueyong, Gabarroca García Alba, Uslu Elif, Liang Ruonan, Spruit Cindy M, Richard Mathilde, Boons Geert-Jan, Wilson Ian A, de Vries Robert P

Abstract excerpt

H5Nx viruses continue to wreak havoc in avian and mammalian species worldwide. The virus distinguishes itself by the ability to replicate to high titers and transmit efficiently in a wide variety of hosts in diverse climatic environments. Fortunately, transmission to and between humans is scarce. Yet, if such an event were to occur, it could spark a pandemic as humans are immunologically naïve to H5 viruses. A...

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PMID: 40232794
DOI: 10.1073/pnas.2419800122
PMCID: PMC12036971

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