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Article

Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity.

Journal of molecular biology - 19 Sept 2008

Stevens James, Blixt Ola, Chen Li-Mei, Donis Ruben O, Paulson James C, Wilson Ian A

Abstract excerpt

Adaptation of avian influenza viruses for replication and transmission in the human host is believed to require mutations in the hemagglutinin glycoprotein (HA) which enable binding to human alpha2-6 sialosides and concomitant reduction in affinity for avian alpha2-3 linked sialosides. Here, we show by glycan microarray analyses that the two mutations responsible for such specificity changes in 1957 H2N2 and 1968...

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Identifiers

PMID: 18672252
DOI: 10.1016/j.jmb.2008.04.016
PMCID: PMC2519951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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