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Dysregulated proteostasis network in neuronal diseases

24 Feb 2023

Abstract excerpt

Long-term maintenance of synaptic connections is important for brain function, which depends on varying proteostatic regulations to govern the functional integrity of neuronal proteomes. Proteostasis supports an interconnection of pathways that regulates the fate of proteins from synthesis to degradation. Defects in proteostatic signaling are associated with age-related functional decline and neurodegenerative...

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PMID: 36910151
DOI: 10.3389/fcell.2023.1075215

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