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Temporal proteomics during neurogenesis reveals large-scale proteome and organelle remodeling via selective autophagy

25 Oct 2021

Abstract excerpt

Cell state changes are associated with proteome remodeling to serve newly emergent cell functions. Here, we show that NGN2-driven conversion of human embryonic stem cells to induced neurons (iNeurons) is associated with increased PINK1-independent mitophagic flux that is temporally correlated with metabolic reprogramming to support oxidative phosphorylation. Global multiplex proteomics during neurogenesis...

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PMID: 34699746
DOI: 10.1016/j.molcel.2021.10.001

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