Article

Mapping the binding site of P2X7 receptor antagonists

2019-01-01

Abstract excerpt

The P2X7 receptor (P2X7R) is a ligand gated ion channel activated by high concentrations of ATP that are usually found in conditions of stress, cellular damage and disease. Selective P2X7R antagonists therefore may have therapeutic potential for treatment of several pathological conditions. Understanding how P2X7R antagonists act on the receptor is useful to facilitate drug design. In this thesis the molecular bas...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5fd45dce-579d-5e7d-9d17-98532c36f0d7
DOI: 10.25392/leicester.data.10303748.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Mapping the binding site of P2X7 receptor antagonistsDOI 10.25392/leicester.data.10303748.v1Read

Unique residues in the ATP gated human P2X7 receptor define a novel allosteric binding pocket for the selective antagonist AZ10606120.Semantic proximity Read

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.Semantic proximity Read

Allosteric modulation of ATP-gated P2X receptor channels.Semantic proximity Read

Structural insights into the allosteric inhibition of P2X4 receptorsSemantic proximity Read

Identification of regions of the P2X(7) receptor that contribute to human and rat species differences in antagonist effects.Semantic proximity Read

Tyrosine 288 in the extracellular domain of the human P2X7 receptor is critical for receptor function revealed by structural modeling and site-directed mutagenesis.Semantic proximity Read

P2X7 Receptor in Hematological MalignanciesSemantic proximity Read

The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential.Semantic proximity Read

Agonist antagonist interactions at the rapidly desensitizing P2X3 receptor.Semantic proximity Read

Molecular Structure and Regulation of P2X Receptors With a Special Emphasis on the Role of P2X2 in the Auditory System.Semantic proximity Read

Molecular dissection of purinergic P2X receptor channels.Semantic proximity Read

Significance of P2X7 receptor variants to human health and disease.Semantic proximity Read