Article

Structural insights into the allosteric inhibition of P2X4 receptors

2023-03-09

Abstract excerpt

P2X receptors are ATP-activated cation channels involved in a variety of physiological functions. Among the seven subtypes of P2X receptors, the P2X4 subtype plays important roles in both the immune system and the central nervous system, particularly in neuropathic pain. Therefore, P2X4 receptors are of increasing interest as potential drug targets, and several P2X4 subtype-specific inhibitors have been developed....

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Literature Corpus work: c61afe2b-85af-5e89-aa8b-a138650716a0
DOI: 10.1101/2023.03.07.531612

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