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Article

The P2X7 receptor in leukemia: pathological mechanisms and therapeutic potential.

Purinergic signalling - 1 Dec 2025

Xue Yanwen, Peng Xiaoxiang, Yan Meng, Du Yanan, Cao Yahui, Zhao Ronglan

Abstract excerpt

The P2X7 receptor is a trimeric ion channel purinergic receptor. It plays a crucial part in the pathophysiology of cancers and a variety of inflammatory diseases and is widely expressed in different cell types. Leukemia represents a type of malignant clonal disorder that impacts the hematopoietic stem cells. Chemotherapy is one of the main treatment methods for leukemia, but there are also many side effects. In...

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Identifiers

PMID: 40844672
DOI: 10.1007/s11302-025-10108-4
PMCID: PMC12722618

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