Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.

doi:10.1007/s11302-020-09730-1

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Article

Contribution of Val/Ile87 residue in the extracellular domain in agonist-induced current responses of the human and rat P2X7 receptors.

Purinergic signalling - 1 Dec 2020

Caseley Emily A, Muench Stephen P, Jiang Lin-Hua

Abstract excerpt

The P2X7 receptor (P2X7R) is an ATP-gated cation channel with a critical role in many physiological and pathological processes, and shows prominent functional differences across mammalian species, exemplified by larger current responses of the rat (r) P2X7R to ATP and its analogue BzATP and a greater sensitivity to agonists compared with the human (h) P2X7R. Here, we showed that substitution of Val87 residue in...

Topics

Animals
HEK293 Cells
Humans
Mutation
Rats
Receptors, Purinergic P2X7

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PMID: 33029714
DOI: 10.1007/s11302-020-09730-1
PMCID: PMC7855165

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