Article

Genetic susceptibility and causes for early-onset breast cancer: insights from genome-wide and phenome-wide analyses

2026-07-31

Abstract excerpt

<h4>Background</h4> Breast cancer diagnosed at a younger age tends to be more aggressive and have worse outcomes. While rare pathogenic variants in multiple susceptibility genes and >200 common variants have been identified for breast cancer, >50% of the familial risk of early-onset breast cancer (EOBC) remains unexplained. Little is known about the EOBC non-genetic risk factors. We aimed to examine the genetic s...

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Literature Corpus work: 5f9bdda9-acbb-5bcf-8cbb-55ac6565d87d
DOI: 10.64898/2026.07.29.26359273

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