Article
Breast cancer genetics: what we know and what we need.
Nature medicine - 1 May 2001
Nathanson K L, Wooster R, Weber B L, Nathanson K N
Abstract excerpt
Breast cancer results from genetic and environmental factors leading to the accumulation of mutations in essential genes. Genetic predisposition may have a strong, almost singular effect, as with BRCA1 and BRCA2, or may represent the cumulative effects of multiple low-penetrance susceptibility alleles. Here we review high- and low-penetrance breast-cancer-susceptibility alleles and discuss ongoing efforts to...
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