Article

Integrative Gene-Centric Analysis of Breast Cancer: High-Confidence Germline Predisposition Genes from Population-Scale Cohorts

2025-09-12

Abstract excerpt

<h4>Background</h4> Heritable breast cancer (BC) predisposition is shaped by high-penetrance genes such as BRCA1 and BRCA2, but many moderate- and low-penetrance genes remain uncharacterized. While over 100 independent loci have been reported, their causal genes are often mixed with spurious identifications. <h4>Methods</h4> Using large-scale, multi-ethnic genomic data from cohorts including the UK Biobank (UKB)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69a66d0c-07cf-59c9-814b-83fa96b94434
DOI: 10.1101/2025.09.10.25335496

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative Gene-Centric Analysis of Breast Cancer: High-Confidence Germline Predisposition Genes from Population-Scale CohortsDOI 10.1101/2025.09.10.25335496Read

Investigation of monogenic causes of familial breast cancer: data from the BEACCON case-control studySemantic proximity Read

Breast cancer genes: beyond BRCA1 and BRCA2.Semantic proximity Read

Functions of Breast Cancer Predisposition Genes: Implications for Clinical Management.Semantic proximity Read

A Review of Whole-Exome Sequencing Efforts Toward Hereditary Breast Cancer Susceptibility Gene Discovery.Semantic proximity Read

Detection of novel germline mutations for breast cancer in non-BRCA1/2 families.Semantic proximity Read

Understanding genetic variations associated with familial breast cancer.Semantic proximity Read

Risk of Breast Cancer Among Carriers of Pathogenic Variants in Breast Cancer Predisposition Genes Varies by Polygenic Risk Score.Semantic proximity Read

Comprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilitiesSemantic proximity Read

Breast cancer germline multigene panel testing in mainstream oncology based on clinical–public health utility: ESMO Precision Oncology Working Group recommendationsSemantic proximity Read

Breast cancer genomic analyses reveal genes, mutations, and signaling networks.Semantic proximity Read

Disease Spectrum of Breast Cancer Susceptibility GenesSemantic proximity Read

Complex Landscape of Germline Variants in Brazilian Patients With Hereditary and Early Onset Breast CancerSemantic proximity Read