Article
Association of Breast and Ovarian Cancers With Predisposition Genes Identified by Large-Scale Sequencing.
JAMA oncology - 1 Jan 2019
Lu Hsiao-Mei, Li Shuwei, Black Mary Helen, Lee Shela, Hoiness Robert, Wu Sitao, Mu Wenbo, Huether Robert, Chen Jefferey, Sridhar Srijani, Tian Yuan, McFarland Rachel, Dolinsky Jill, Tippin Davis Brigette, Mexal Sharon, Dunlop Charles, Elliott Aaron
Abstract excerpt
Importance: Since the discovery of BRCA1 and BRCA2, multiple high- and moderate-penetrance genes have been reported as risk factors for hereditary breast cancer, ovarian cancer, or both; however, it is unclear whether these findings represent the complete genetic landscape of these cancers. Systematic investigation of the genetic contributions to breast and ovarian cancers is needed to confirm these findings and...
Topics
- Adult
- Aged
- Biomarkers, Tumor
- Breast Neoplasms
- Breast Neoplasms, Male
- Case-Control Studies
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease