Article

Interaction of inherited genetic variants in the NLRP3 inflammasome/IL-6 pathway with acquired clonal hematopoiesis to modulate mortality risk in patients with HFrEF

2023-05-05

Abstract excerpt

<h4>Aims</h4> Clonal hematopoiesis (CH), defined as the presence of an expanded blood cell clone due to acquired somatic mutations in leukemia driver genes, was shown to be associated with increased mortality in patients with chronic ischemic heart failure with reduced ejection fraction (HFrEF). Mechanistically, circulating monocytes of mutation carriers display increased expression of proinflammatory genes involv...

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Literature Corpus work: 1ca2c91f-4f0a-51ad-af19-70d0be009b96
DOI: 10.1101/2023.05.03.23289436

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