Article

Role of X chromosome and dosage compensation mechanisms in complex trait genetics

2025-01-17

Abstract excerpt

The X chromosome (chrX) is often excluded from genome-wide association studies due to its unique biology complicating the analysis and interpretation of genetic data. Consequently, the influence of chrX to human complex traits remains debated. Here, we systematically assessed the relevance of chrX and the effect of its biology on complex traits by analyzing 48 quantitative traits in 343,695 individuals in UK Bioba...

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Literature Corpus work: 5f89a1d8-cb23-5c50-acfa-22e5c65ca95d
DOI: 10.1101/2025.01.16.633321

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