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Article

Chromosome X-wide association study identifies Loci for fasting insulin and height and evidence for incomplete dosage compensation.

PLoS genetics - 1 Feb 2014

Tukiainen Taru, Pirinen Matti, Sarin Antti-Pekka, Ladenvall Claes, Kettunen Johannes, Lehtimäki Terho, Lokki Marja-Liisa, Perola Markus, Sinisalo Juha, Vlachopoulou Efthymia, Eriksson Johan G, Groop Leif, Jula Antti, Järvelin Marjo-Riitta, Raitakari Olli T, Salomaa Veikko, Ripatti Samuli

Abstract excerpt

The X chromosome (chrX) represents one potential source for the "missing heritability" for complex phenotypes, which thus far has remained underanalyzed in genome-wide association studies (GWAS). Here we demonstrate the benefits of including chrX in GWAS by assessing the contribution of 404,862 chrX SNPs to levels of twelve commonly studied cardiometabolic and anthropometric traits in 19,697 Finnish and Swedish...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Dosage Compensation, Genetic

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Source

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Identifiers

PMID: 24516404
DOI: 10.1371/journal.pgen.1004127
PMCID: PMC3916240

Genes

ATRX
FGF16
MAGT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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